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Tailored approaches may help alleviate these side effects, support healthy BC, and improve long-term treatment engagement [15, 27]

NICE guidelines recommend specific GLP-1 receptor agonists as part of a comprehensive approach to diabetes management (NG28) and, in specific circumstances, for weight management in individuals with obesity or overweight with comorbidities (TA875 for semaglutide, TA664 for liraglutide)

Characterization of GLP-1 effects on -cell function after meal ingestion in humans

Follow-up will occur over 12 months, with an additional phone call 30 days after treatment discontinuation

Semaglutide induced central c-Fos activation in 10 brain areas, including hindbrain areas directly targeted by semaglutide, and secondary areas without direct GLP-1R interaction, such as the lateral parabrachial nucleus

Metabolism-Clinical and Experimental